北京時間11月25日淩晨，欧冠2021-22賽季歐冠小組賽第5輪戰罷 ，强英各個小組的超队出線形勢也是趨於明朗。從目前的皇仁形勢來看 ，歐冠16強已確定11席 ，文巴曼城、黎列利物浦 、剩席曼聯、虚位切爾西 、欧冠國米、强英尤文、超队皇馬 、皇仁拜仁 、文巴巴黎、黎列阿賈克斯 、剩席葡萄牙體育 ，其中來自英超的有4支球隊 ，來自意甲的有2支球隊，西甲 、德甲 、法甲 、荷甲以及葡超各一支球隊 。
具體出線情況如下 ：
A組 ：曼城 、巴黎分列前二出線 ，確定排名
B組 ：利物浦鎖定第一
C組 ：阿賈克斯 、葡體分列第二出線 ，確定排名
D組 ：皇馬 、國米前二出線，排名未定
E組 ：拜仁鎖定第一
F組 ：曼聯鎖定第一
G組 ：暫無出線球隊
H組 ：切爾西 、尤文前二出線 ，排名未定
歐冠小組賽末輪將於北京時間12月8日淩晨開打 ，北京時間12月13日 ，歐足聯將舉行1/8決的抽簽，屆時歐冠16強戰的對決形勢將揭曉 。1/8決賽將於2022年2月15日 、16日 、22日 、23日進行首回合比賽，3月8日 、9日、15日 、16日進行次回合比賽 。
抽簽規則 ：
1 、8個小組第一為種子隊（1/8決賽先客後主） ，8個小組第二為非種子隊；
2 、任何球隊都不會抽到同小組對手及同協會球隊 ，如有其他限製將會在抽簽儀式前公布 。
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